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In contrast, insomnia is a clinically defined disorder, diagnosed when an individual reports the following criteria 7 : Difficulty initiating or maintaining sleep, or experiencing nonrestorative sleep, despite adequate opportunity Daytime functional impairments resulting from nocturnal sleep disturbance 8

Importantly, the mean lesion volume (representing the largest lesion for each mouse) for HFD-fed recipients was significantly lower (by ~5-fold) than their CD-fed counterparts (Figure 1D)

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doi: 10.3390/pr12102223 191 PettinatoE.BhnertP.BergI

Contributions of the brain angiotensin IV-AT4 receptor subtype system to spatial learning. Journal of Neuroscience , 1999.