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The evidence for meaningful additional benefit from niacinamide inclusion is limited, but like glycine, it adds minimal cost and no significant risk

In one human study, some of the reported side effects of chanca piedra supplementation included: abdominal pain painful urination blood in the urine nausea Abdominal pain was by far the most common, with the others being much less commonly reported ( Chanca piedra may also reduce blood sugar and blood pressure levels, so it should be used with caution if youre on a blood pressure or blood sugar lowering medication ( Keep in mind that supplements arent regulated by any government organizations, so theres little oversight to ensure that the label is an honest representation of whats in the supplement

Among other benefits, carnosine helps reduce fatigue and improve overall physical performance