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These studies suggest that low circulating IGF-I bioactivity and/or abnormalities of IGF-I signaling in elderly subjects, may play an important role in age-related sarcopenia and osteopenia, where the substitutive IGF-I treatment may be a suitable therapeutic strategy, although this apparent IGF-I resistance may dampen this aim

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82001836, 82071933 and 82227803 to X.S., and 82030050, T2394534 to Y.Z.), the National Key Research and Development Program of China (2022YFC3400100 to Y.Z.), the Science and Technology Committee Foundation of Shanghai (grant No

No, Results take time, usually weeks to months