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A subcutaneous (SC) formulation of daratumumab is approved for use and can be administered over ~ 5 min (QW for 8 weeks, Q2W in weeks 924, and Q4W from week 25, as monotherapy or combined with Pd or lenalidomide-dexamethasone) [14]

doi: 10.1016/J.BBCAN.2021.188556 32 WangHGuoMWeiHChenY

While IR and IGF-1R share many downstream signaling pathways, there are some preferential differences between phospho-signaling downstream of the two receptors that contribute to unique effects of both the hormones and hormone receptors 16,19

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