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These mice provide an excellent model for studies on transfection efficiency, transfer sequences and gene expression levels

doi: 10.1038/nature13568 18 WangXChenLWangHCaiWXieQ

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The 3 children with MD that died (aged 66192 months) while being on KD all had POLG- related Alpers disease, an early lethal disorder with a median age at death of 16 (range 1181) months [48]