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10.1128/AEM.70.11.6738-6747.2004 Martin-Galiano AJ, Overweg K, Ferrandiz MJ, Reuter M, Wells JM, De la Campa AG: Transcriptional analysis of the acid tolerance response in Streptococcus pneumoniae

for instance, free cysteine residues in proteins may undergo oxidation to form disulfide bonds and other redox modifications, which can change protein activity and impact the activation of signaling pathways [130, 131]

Therefore, melasma treatment, especially in patients with dark skin types classified as Fitzpatrick types IV to VI, is challenging due to the possibility of relapse and also susceptibility to post-inflammatory hyperpigmentation (PIH) (Rodrigues and Pandya, 2015)