importance of glutathione peroxidase The biological and peroxiredoxin backup systems in bivalves during peroxide exposure Flow chart showing mechanism of

In non-enzymatic processes, the H 2 O 2 combines with Fe 2+ (e.g., ferritin protein) or Cu 2+ (e.g., ceruplasmin protein) ions in the Fenton reaction, where it accepts an electron from metal ions to form highly reactive (t 1/2 = 10 9 s) HO radical and HO + ion and thus are highly reactivity in the mitochondrial matrix [16]

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NNMT inhibition by 5-Amino-1MQ preserves the cellular nicotinamide pool important for NAD+ biosynthesis and conserves the methyl-donor pool by reducing SAM consumption

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