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Considering that these metabolites may be related to confounding factors of aforementioned clinical features, we made linear models with covariate adjustment analysis of bacteria in the DCG (Supplementary Figure S4)

The results showed that KDM2B, functioning in the context of ncPRC1.1, regulates a network of epigenetic and transcription factors, which control a host of metabolic enzymes, including those involved in the SGOC, glutamate, and GSH metabolism