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Description

These are important observations because if the normal endogenous CoQ concentration is limiting, then increasing it could improve respiration, possibly even in the presence of defects in mitochondrial function

Ito Y, Bethea NW, Abril ER, McCuskey RS

Microbiome 10(1):160

In OA, chondrocyte activity declines, leading to reduced synthetic capacity and increased secretion of matrix-degrading enzymes such as matrix metalloproteinase 13 (MMP-13) and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)