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Human and Animal Rights All authors hereby declare that there are no ethical concerns related to human or animal rights in this study

Biochem Pharmacol 58: 5968

This reduced bone response to the stimulatory effects of GH via IGF-1 has been linked to decreased VEGF expression and diminished vascularization in the primary ossification zone of rats with renal insufficiency.102 In the same way, intensive treadmill exercise improves linear bone growth in a rat model of renal insufficiency (5/6Nx)

The AUC (area under the receiver operating characteristic curve) value of this model in the validation set was 0.67 (71% sensitivity and 63% specificity)