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However, in conditions like ischemic stroke and spinal cord injury, CHAC1 promotes neuronal damage by inducing ferroptosis through the depletion of GSH, a critical antioxidant, exacerbating oxidative stress and worsening the injury (Mei et al., 2017

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Oxidative stress and neuroinflammation play a crucial role in the initiation and development of various neurodegenerative diseases [56]