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Edible insects, such as mealworms and crickets, may also enrich the human diet with folate 171,172,173

That is, xCT inhibitors may exhibit anticancer properties against cancer cells with elevated GLUT1 expression in a high-glucose tumor environment, whereas glucose deprivation blocks ferroptosis-induced cell death [18,19] [Figure 2B]

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In addition, the gain-of-function Pik3ca H1047R mutant outcompetes normal esophageal cells in vivo, consistent with Pik3ca deletion reducing cell fitness 34

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