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The peptide is engineered with a fatty-acid moiety to extend its circulation time (half-life ~6 days), allowing for once-weekly dosing [2]

Cancer Lett 266:5359 Niu X, Stancliffe E, Gelman SJ, Wang L et al (2023) Cytosolic and mitochondrial NADPH fluxes are independently regulated

3.2 Chemical instability under physiological and processing conditions Curcumin is notably unstable in both physiological fluids and during standard processing conditions, undergoing rapid degradation that compromises its therapeutic efficacy and shelf stability