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Then alkylation would mean initiation of cancer, and the action of a carcinogen after exerting its alkylating effect, or of another nonalkylating carcinogen, would be the promotion of cancer

[151] [152] This research subsequently led to the synthesis of the antifolate aminopterin, which was used to treat childhood leukemia by Sidney Farber in 1948

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In other words, they shouldnt cause any prostate enlargement or similar issues that are common for steroids

Hepatic stellate cell promoted hepatoma cell invasion via the HGF/c-Met signaling pathway regulated by p53