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Thus, we tested in genetic mouse models whether a moderate increase in VEGFA expression (~two to threefold, as it occurs in response to hypoxia or oxidative stress in aged tissues) leads to increased agerelated progressive pathologies in the lens and the retina, and whether genetic targeting of NLRP3 inflammasome components or of its regulators can inhibit the manifestation of these common but distinct aging eye pathologies

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The pathogencontaining region bordered to a proinflammatory region, which was enclosed by an antiinflammatory region

Dysfunction or weakness in these muscles can further exacerbate imbalanced muscle activation patterns, indirectly increasing the load on the ACL