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ROS are reactive forms of oxygen which include superoxide anion radical, hydrogen peroxide, singlet oxygen and hydroxyl radical, they are usually produced during normal metabolism of oxygen inside the mitochondria [116]

Interim analysis of the EAGLE trial: an open-label study to assess the long-term safety and tolerability of bardoxolone methyl in patients with alport syndrome: PO1300

Patients were randomized to receive one of the following: Treatment continued in both arms until disease progression or unacceptable toxicity

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Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions