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This genetic defect is more common in South Asians and those of African origin, and unlike transcobalmin deficiency, is associated with other B12 biomarkers in the normal range and no clinical symptoms

Prompt parenteral B12 treatment should be initiated without delay in such cases, in line with BSH guidance, to minimise the risk of permanent neurological damage

NHS treatment protocols involve intramuscular loading doses followed by maintenance therapy, with frequency determined by underlying cause and severity

These medications mimic glucagon-like peptide-1, an incretin hormone naturally released by the intestines in response to food intake