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In the bilateral common carotid artery occlusion/reperfusion (BCCAO/R) model, GAL treatment improved learning and memory in the Morris water maze (MWM) test, reduced lipid peroxidation, and upregulated SLC7A11 and GPX4 expression

Fasting serum glucose and lipids also did not differ significantly between the groups, but the Ow/Ob group had a higher serum insulin concentration (14.6 (10.5, 22.2) mU/L) compared to normal-weight subjects (9.9 (7, 12.1) mU/L, P = 0.006), and also higher HOMA-IR (P = 0.014) (Table 1)

10.1111/acel.14096 50 SchaumN.LehallierB.HahnO.PlovicsR.HosseinzadehS.LeeS

Greater absorption or a change in a glutathione biomarker can support biological plausibility, but meaningful claims about symptoms, disease prevention or longevity require clinical-outcome research