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Naturally occurring form in foods and in the body

Agathisflavone has been found to significantly increase the number of neuronal progenitor cells and mature neurons without increasing astrocytes or microglia, and also to effectively reduce the inflammatory factors factor-, interleukin-6, interleukin-1, NO, and PGE2 ( in vitro and enhances the neuroprotective properties of microglia and astrocytes

Meanwhile, HIF-1 increases the transcription of SLC7A11 and HO-1, which both protect from ferroptosis through decreasing ROS and increasing GSH (Feng et al