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FIGURE 3 FIGURE 4 FIGURE 5 It is known that NPM interacts with ARF in the nucleolus, and after DNA damage, both can translocate to the nucleoplasm and to cause disruption of p53-HDM2 interaction (Kurki et al., 2004b), which allow p53 stabilization and activation by, for example, phosphorylation in Ser15 (Loughery et al., 2014)

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In animal experiments, each larva was considered to be an independent biological replicate, and at least six animals were used per imaging modality (spinning-disc confocal and two-photon microscopy)

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Stackpole et al