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Furthermore, a reduction in symbiotic bacteria such as Faecalibacterium prausnitzii and overgrowth of pathogenic bacteria have been observed in the gut of IBD patients, with host-associated gene mutations impairing the recognition and clearance of the gut microbiome

Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

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