lipid metabolism in c.elegans Changes driven by steroid signalling modulate proteostasis in C. elegans | EMBO Reports Modulation of lipid biosynthesis contributes

Contractor R, Konopleva M, Samudio I, Safe S, Andreeff M

To probe whether NO, ROS and lipid peroxide accumulation is involved in BSO-induced ferroptosis, we determined the time- and concentration-dependent changes in cellular NO, ROS, lipid peroxides, mitochondrial ROS, and mitochondrial lipid peroxides by jointly using fluorescence microscopy and analytical flow cytometry

During this process, ferroptotic cells display shrunken mitochondria, exhibiting reduced or absent cristae, increased membrane density, and rupture of the outer mitochondrial membrane

Additionally, acute caffeine treatment suppresses phagocytosis in human mononuclear phagocytes, thereby promoting an anti-inflammatory response [93]

Effect of sulforaphane on UC-induced DNA polymerization UC results in a 3.24- and 3.12-fold increase in the gene expression of mTOR and cyclin D1 associated with a 2.84- and 3.62-fold increase in the protein levels of both compounds, respectively, as compared with the control group