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As the primary source of inflammatory factors in the liver, activated Kupffer cells release large amounts of inflammatory factors such as TNF-, IL-1, and IL-6, leading to cascading amplification of inflammatory signals, thereby inducing hepatocyte apoptosis and necrosis

Although the number of species detected in the sample increased (increased species richness), some species may over proliferate, leading these species to dominate the community, thus reducing evenness (the Simpson index decreased)

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