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Without a substrate, the phosphohistidine was suggested to reflect an autoinhibited state of PLD 26 , as the phosphorylation blocks the nucleophilic atom to initiate the first attack

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In the next step (step 2), the resolving Cys forms an intramolecular disulfide bond with the C P by releasing H 2 O

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Adult ICU patients meeting Sepsis-3 criteria and diagnosed with delirium during ICU stay were included