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[1] A frequently employed regimen involves applying approximately 1-2 mL of the 0.5 % solution to affected scalp regions once to twice daily, preferably on clean, dry skin in the evening

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The bupropion component can cause dry mouth, insomnia, and tremor in some patients

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Metabolic: Hyperglycemia advanced glycation end-products (AGEs), polyol pathway activation, oxidative stress, mitochondrial dysfunction nerve ischemia and axon loss in diabetic neuropathy per ADA Standards of Care