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Abstract Hepatocyte growth factor (HGF) and its tyrosine kinase receptor, encoded by the MET cellular proto-oncogene, are expressed in the nervous system from pre-natal development to adult life, where they are involved in neuronal growth and survival

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these patients develop rapidly progressive childhood-onset dystoniaparkinsonism, with clinical findings supported by distinctive brain MRI findings and post-mortem evidence of neurodegeneration 52