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Besides the acute phase gastrointestinal effects which may lead to up to 10% of people discontinuing the drugs, there are other potential GI side effects of obstruction, excessive loss of muscle mass, and potentially association with some eye disease adverse events

Ipamorelin a selective GHS-R1a agonist with a profile regarded as particularly clean (minimal co-secretion of cortisol and prolactin)

Peptides may be lower-risk in some situations because they often stimulate natural hormone pathways rather than directly replacing hormones

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Management of undescended testes: European Association of Urology/European Society for Paediatric Urology guidelines