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for long-term metabolic outcomes Biohacker Microdosing Dose: 0.5 1 mg every 3 days (variant 5 mg pen = 1530 clicks / variant 10 mg pen = 510 clicks / variant 15 mg pen = 510 clicks) Duration: 4 8 weeks Frequency: Every 3 days Cycle Interval: Repeat after 1 month Goal / Description: Used experimentally to assess mild appetite control and metabolic priming Maintenance Phase Dose: 2.5 5 mg (variant 5 mg pen = 76152 clicks / variant 10 mg pen = 2550 clicks / variant 15 mg pen = 2550 clicks) Duration: Variable Frequency: 1 weekly Cycle Interval: Continuous Goal / Description: Sustain achieved body composition and metabolic balance

Treated mice show a 15%20% increase in basal metabolic rate and elevated energy expenditure, with effects positively correlated with NNMT inhibition