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While MSCs may be an attractive alternative source to ESCs in cell-based therapies, difficulty in continued proliferation in vitro , off-target differentiation into other cell types, fibrotic changes, and cellular senescence are issues that have yet to be fully addressed

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Hepatoma cell lines, such as HepG2, in general display lower expression levels of hepatic phase I and phase II enzymes compared with primary hepatocytes, thus questioning their informative value for the situation in vivo

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To clarify how the TSS pathway is activated, we first evaluated the effects of hypoxia in the presence of supraphysiological concentrations of cystine