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P.2005Yeast ATP-Binding Cassette Transporters: Cellular Cleaning Pumps.400460484 28

10.1094/MPMI.2000.13.12.1380 21 CombetE.El MesmariA.PrestonT.CrozierA.McCollK

The activation of PARP induces major neurotoxicity, as evidenced by the extreme protection against brain damage in PARP knockout mice subjected to transient MCA occlusion (up to 80% reduction of infarct volume) (349, 360)

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The risk, benefits and limitation of genetic testing should always be discussed with the patient Patients with confirmed LS, or in those where it is highly suspected but testing is unavailable, require colonoscopic surveillance