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Gaede P, Lund-Andersen H, Parving HH, Pedersen O

We also found human and mouse -cells and -cells express the L-type amino acid transporter (LAT) isoforms required for cellular uptake of catecholamine precursors (e.g., L-DOPA)

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The compound's development represents years of medicinal chemistry optimization, resulting in a 10-fold improvement in potency over parent compounds while maintaining excellent safety margins in preclinical studies

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