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10.1016/j.jtemb.2019.126418 237 SkjrringeT.BurkhartA.JohnsenK

Future functional studies should assess whether associations between these bacteria concentrations and brain volumes reflect causal relationships

Aging is commonly associated with gut dysbiosis, marked by reduced microbial diversity and a decline in beneficial bacterial populations, which has been linked to cognitive decline and increased frailty (Claesson et al., 2012

MGMT promoter hypomethylation resulted in the abnormal expression in gene level, which reduced its ability to repair damaged genes, further exacerbating the stability of the chromosomes