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No habit-forming tendencies were reported

Acknowledgements The authors acknowledge the So Paulo Research Foundation (FAPESP), grant number 17/12105-2,21/03265-1 and 25/05539-2, and the Faculty of Animal Science and Food Engineering (FZEA-USP)

They are present at varying frequencies and can contribute significantly to the global burden of anaemia via clinically significant homozygous forms and the more common, usually clinically silent carrier forms 243 (Table 3)