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53,54 Recent research indicates that GPCRs can bind to various single transmembrane accessory proteins to regulate their biological functions such as ligand binding, transducer coupling, and intracellular signaling

These drugs are commonly referred to as biased ligands. For instance, G protein-biased -opioid receptor (OR) agonists are of remarkable clinical relevance as they enhance analgesia effects and reduce adverse reactions associated with the activation of -arrestin pathways, in contrast to morphine

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[2] The FDA approves manufactured drugs that undergo extensive clinical trials