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Similarly, one study showed that Tmed4(-/-) mice had endogenous regulatory T (Treg) cells that shifted toward a more inflammatory phenotype with enhanced anti-tumor activity in a colorectal cancer model (84)

& Miao, W

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Inhibition of serine biosynthesis through CRISPR- Cas9 -mediated knockout of PHGDH resulted in a ~250-fold reduction in the half-maximal inhibitory concentration (IC 50 ) for Rylaze, indicating heightened sensitivity to crisantaspase therapy

J Biol Chem 277:3916339168 MacDonald MJ, Efendic S, Ostenson CG (1996) Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat