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In recent years, KD has been demonstrated to be beneficial in several neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) [3]

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Moreover, although AMPK1 and AMPK2 subunits function redundantly, AMPK1 depletion is sufficient to reduce total AMPK level and sensitize the cancer cells to glucose starvation

7 neutrophil-derived mediators that cause tissue damage, such as myeloperoxidase (MPO), correlate with disease activity

More than 40 genetic mutations have been reported implicated in ALS pathophysiology, such as C9orf72 (chromosome 9 open reading frame 72), SOD1 (superoxide dismutase 1), TARDBP (TAR DNA-binding protein 43, coding for TDP43), and FUS (fused in sarcoma