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The established safety profiles of these GH secretagogues in defined populations make them particularly attractive candidates for off-label use in musculoskeletal recovery

At the same time, the extreme production of ROS impaired the degradation of Nrf2, which is mediated by kelch-like epichlorohydrin-associated protein 1 (Keap1) [80], resulting in the accumulation of Nrf2 that upregulated HO-1 production [81, 82], as confirmed in our study