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doi: 10.3390/ijms232314627 101 SchijlenE.Ric De VosC.JonkerH.Van Den BroeckH.MolthoffJ.Van TunenA.et al

Regarding dying-back degeneration, as previously described, axonal mitochondrial dysfunction triggers this form of cell deathaxonal terminals first undergo swelling and fragmentation, followed by the spread of degenerative changes to the soma

These findings point to the possibility that these deletions, by interfering with the skin's protective barrier function, exacerbate the condition (De Cid et al