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Petersburg Institute of Bioregulation and Gerontology, Epitalon is derived from Epithalamin , a natural peptide complex extracted from the pineal gland an endocrine organ responsible for regulating circadian rhythms and hormonal cycles Khavinson, Biogerontology , 2003

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Minor changes in the setpoint of the axis caused by programming of the fetus exposed to intra-uterine growth retardation may predispose the individual for poor linear growth and later metabolic disease, insights that the pediatrician should be aware of and consider in order to improve health and prevent later disease