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MOTS-c(no longer available to prescribe) is a mitochondrial peptide that causes increased fat burning, increased energy, and reduces insulin resistance/diabetes

The most common causes of methane SIBO are conditions that impair motility, digestion and/or outflow, such as: Food poisoning (most common) Traumatic brain injury Hypothyroidism Diabetes Mold Chronic infections (parasites, Lyme) Scleroderma Ehlers-Danlos syndrome Disordered eating Abdominal surgery Endometriosis Ileocecal value dysfunction Impaired digestion (HCL, enzymes and bile) Medications such as PPIs, opioids, tricyclic antidepressants Well discuss the way in which we identify and address root causes of methane SIBO later in this article

M30 has also decreased elevated levels of inflammatory cytokines in a mouse model of Alzheimers disease (Pimentel et al., 2015)

Treatments for PIH could include: retinoids, alpha hydroxy acids, beta hydroxy acids, and azelaic acid (dicarboxylic acid)