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for example, DA and serotonin each display roles that span both modulatory and, respectively, excitatory or inhibitory effects, emphasizing the complexity of neurotransmitter impact on brain function

We also generated two additional 1a R -IN-8 derivatives, in which the ATP-pocket binding moiety was linked to the cyclic warhead scaffold via an additional methylene group ( 1a R -IN-8), making the distance between these two presumably less optimal, and this was further modified by changing the amide to an ester group at C2 ( 1a R -IN-8

Bndicte C, Jean-Yves J, Pierre M, Nadine P, Pierre G, Patrick N et al

21 March 2023