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In addition, the blood supply to the liver via the portal system has a lower glutamine concentration because the small bowel has already extracted some of the glutamine for its own use

Efficacy of daily low-dose sildenafil for treating interstitial cystitis: results of a randomized, double-blind, placebo-controlled trial treatment of interstitial cystitis/painful bladder syndrome with low-dose sildenafil

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doi: 10.1016/j.foodchem.2020.127364

In Germany, it is used for spring cure while in Mexico it is used as an anti-diabetic [24]