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Methionine S-adenosyl methionine (SAM), a methionine metabolite, may interact with opioids, antipsychotics, amphetamines, and antidepressants to cause an overabundance of serotonin to accumulate in the body

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Nutritional factors that may be useful to consider in pain management - evidence indicates substantial relief of neuropathic pain by thiamine, pyridoxine and cyanocobalamin separately, and in combination there was a synergistic benefit, low B12 exacerbates elevated TNF- which is an inflammatory response marker

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