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The liver and kidneys collaborate through the liver-kidney axis, with metabolic intermediates produced by the liver, such as -aminoadipic acid, further processed by the kidneys

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Phenylalanyl-tRNA synthetase editing defects result in efficient mistranslation of phenylalanine codons as tyrosine

This flexibility is a hallmark of metabolic health and is often impaired in individuals with obesity or insulin resistance

We demonstrated ligand efficacy-dependent changes to equilibria between inactive and activation-intermediate (pre-active) receptor states but observed significant differences between agonist-bound and nanobody-bound ternary complex spectra