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Lill and Freibert, 2020) have observed biochemical and morphological characteristics of ferroptosis in the brains of AD patients or mice, including iron metabolism imbalance, glutathione (GSH) degradation, inactivation of glutathione peroxidase 4 (GPX4) leading to increased reactive oxygen species (ROS), lipid peroxidation, and mitochondrial abnormalities

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Current Treatment Options in Cardiovascular Medicine 19: 58

Conclusion As weve explored in this blog post, glutathione is a powerful antioxidant that plays a crucial role in cellular health and detoxification

Notably, metabolically activated ATMs express lysosome-associated programs, promote inflammation, and participate in the clearance of dead adipocytes through lysosomal exocytosis, highlighting that ATMs responses to obesity reflect specialized adaptations to lipid-rich, damaged tissue environments rather than a simple shift between canonical activation states (114)