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It is difficult to determine whether our findings are the result of increased flux from a synthesizing enzyme, decreased flux toward a consuming enzyme, or alteration in transport of a metabolite into or out of cells or tissues

Cilostazol elevates intracellular cyclic nucleotides, and increased amounts of these nucleotides have been demonstrated to diminish ROS production and cellular dysfunction

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Complementary efforts by consortia such as the Radiological Society of North Americas Quantitative Imaging Biomarker Alliance (QIBA) [540] and the European Imaging Biomarker Alliance (EIBALL) [541] have produced harmonized frameworks for quantifying amyloid plaque burden through functional imaging

Ammonia toxicity in fish