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Treatment with rapamycin reverses this process by downregulating YY1 expression

Virus injection and glutamate imaging AAV2/1.hSynapsin.iGluSnFR A184S 65 was a gift from Loren Looger (HHMI/Janelia), AAV1.hSyn.FLEX.iGluSnFR3.v857.PDGFR.codonopt and AAV1.hSyn.Cre.WPRE.hGH were purchased from Addgene (Cat#175180-AAV1 and Cat#105553-AAV1)