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Jun 2022;10(6):442-456

In trials that added it to injected insulin, basal insulin requirements fell roughly 60% to 80% while control improved. Low-blood-sugar risk therefore tracks the insulin or sulfonylurea used alongside tirzepatide more than the tirzepatide dose itself

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In contrast, Nrf2 is a stress-induced transcription factor responsible for maintaining cell metabolism, redox and protein balance, and controlling the expression of genes that counteract oxidative and electrophilic stress (Dodson et al., 2019)