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Furthermore, Mao QQ et al

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Conversely, mutations amplify 2HG by diminishing mitochondrial citrate availability, thereby disrupting glycolysis and reducing acetyl-CoA formation (122)

Determination of the activities of enzymatic antioxidants Superoxide dismutase (SOD) was assayed according to the method of Marklund et al.39 Pyrogallol autooxidizes rapidly in an aqueous solution at a fast rate with higher pH (pH=8.0) to produce several intermediate products

Overall, DMARDs are significant agents within OA therapy which play a role in modulating inflammatory pathways, immune activation and stress-response signaling