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In a 2-year trial, acute pancreatitis was reported in 8 semaglutide-treated patients (0.27 cases per 100 patient-years) and 10 placebo-treated patients (0.33 cases per 100 patient-years), both on a background of standard of care.1 In trials of patients receiving oral semaglutide, pancreatitis was reported as a serious adverse event in 6 patients (0.1 events per 100 patient-years) receiving semaglutide versus 1 in comparator-treated patients (less than 0.1 events per 100 patient-years)

The initial research, conducted by an Australian company called Metabolic Pharmaceuticals, was incredibly exciting

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(b) Reliability and Case Minimum In this section of this final rule, we describe the case minima we proposed for the episode-based measures we proposed to adopt and modify in the CY 2025 PFS proposed rule and are finalizing in section IV.A.4.e.(2) of this final rule, as discussed previously

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